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  • Title: Comparative pharmacokinetics of zimelidine and desipramine in man following acute and chronic administration.
    Author: Potter WZ, Calil HM, Extein I, Zavadil AP, Goodwin FK.
    Journal: Psychiatry Res; 1979 Dec; 1(3):273-81. PubMed ID: 298355.
    Abstract:
    Single dose and steady-state pharmacokinetics of zimelidine and desipramine were compared in eight depressed patients who were subjects in a double-blind crossover study. Within the same patient, there was no relationship between the pharmacokinetics of desipramine (pharmacokinetically similar to all other tricyclic antidepressants) and those of zimelidin, a bicyclic antidepressant. The weight-corrected dose of zimelidine gives a reasonable index of the concentration of its active metabolite norzimelidine, which predominates over zimelidine by a ratio of approximately 3 to 1. The variation in steady-state concentration of norzimelidine for a given dose of zimelidine in adults is about twofold and can be reduced by correcting for weight.
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