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  • Title: Inhibitory action of phosphatidylinositol on synaptosomal (Na+ + K+)-ATPase activity.
    Author: Nishikawa T, Goto M, Shimizu S.
    Journal: Biochem Biophys Res Commun; 1985 Jan 31; 126(2):893-900. PubMed ID: 2983696.
    Abstract:
    Phosphatidylinositol and several other phospholipids were tested for their ability to influence the (Na+ + K+)-ATPase activity of the cortical synaptic membrane from rats at various levels of free Ca2+. Phosphatidylinositol, but not phosphatidylethanolamine, phosphatidylcholine nor phosphatidylserine, markedly inhibited this enzyme activity, when the free Ca2+ concentration in the incubation media was less than 2.5 X 10(-6) M. This result suggests that phosphatidylinositol may play a role in the depolarization and/or the release of neurotransmitters or intracellular substances in the brain.
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