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  • Title: Characterization of pyrophosphate exchange by the reconstituted adenine nucleotide translocator from mitochondria.
    Author: Krämer R.
    Journal: Biochem Biophys Res Commun; 1985 Feb 28; 127(1):129-35. PubMed ID: 2983704.
    Abstract:
    The transport of inorganic pyrophosphate (PPi) by the adenine nucleotide translocator from beef heart mitochondria was studied in a reconstituted system. The transport of PPi is dependent on appropriate transmembrane substrates. The activity of PPi exchange is about one tenth as compared to the ADP/ATP exchange, whereas the transport affinity for PPi is very low (2-5 mM). The adenine nucleotide carrier catalyzes a strict counterexchange of PPi and nucleotides with an exchange stoichiometry close to 1. The inhibitor specificity of PPi exchange is comparable to that of ADP/ATP exchange.
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