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  • Title: [The nature of thyroid hormone receptors. The role of serum thyroxine binding prealbumin in the realization of the hormonal effect].
    Author: Azimova ShS, Petrova OS, Abdukarimov A.
    Journal: Biokhimiia; 1985 Jan; 50(1):114-121. PubMed ID: 2983781.
    Abstract:
    Data from determination of molecular weight and competitive displacement suggest that T3 and T4 are bound to the same protein in chromatin. It was shown that the antigenic determinants of T3 and T4 for the chromatin-binding protein coincide with those for blood serum thyroxine-binding prealbumin (TBPA). It was found also that the binding either to T3 and T4 decreases proportionally to the amount of the TBPA removed from the subcellular fractions. It may thus be concluded that blood serum TBPA is responsible for the binding to T3 and T4 as well as for the realization of the hormonal response.
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