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  • Title: [Changes in the cAMP-dependent phosphorylation system of myocardial sarcoplasmic reticulum components during circulatory hypoxia].
    Author: Antipenko AE, Lyzlova SN.
    Journal: Biokhimiia; 1985 Jan; 50(1):12-6. PubMed ID: 2983782.
    Abstract:
    The dissociation of the holoenzyme of the cAMP-dependent protein kinase was induced by the adrenaline-stimulated endogenous cAMP synthesis. This dissociation was impaired in a hypoxic muscle. The elevated proteolytic activity in the hypoxic area was found to be associated with the reduction of the 33P incorporation into phospholamban in the presence of 10(-6) M cAMP. No changes were observed when protein kinase was added to the incubation mixture. A correlation between the degree of phospholamban phosphorylation and its susceptibility to proteolysis was demonstrated.
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