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  • Title: Effect of urapidil on beta-adrenoceptors of rat atria.
    Author: Verberne AJ, Rand MJ.
    Journal: Eur J Pharmacol; 1985 Jan 22; 108(2):193-6. PubMed ID: 2984023.
    Abstract:
    The effects of the antihypertensive drug urapidil were studied on chronotropic responses to isoprenaline in rat isolated atria. Urapidil (1-30 microM) antagonized the responses to isoprenaline competitively, and the pA2 value was 6.05. Thus, in addition to its alpha 1-adrenoceptor blocking action for which the pA2 value is about 7, urapidil has beta-adrenoceptor blocking activity.
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