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  • Title: Substitution reactions of 99mTcNCl-4--A route to a new class of 99mTc-radiopharmaceuticals.
    Author: Baldas J, Bonnyman J.
    Journal: Int J Appl Radiat Isot; 1985 Feb; 36(2):133-9. PubMed ID: 2984125.
    Abstract:
    The preparation of sodium tetrachloronitridotechnetate Na[99mTcNCl4] is described. This complex may be used for the preparation by a substitution route of 99mTc-radiopharmaceuticals containing a Tc-nitrido(TcN) group. The labelling procedure was demonstrated by the preparation of [99mTcN]MDP, [99mTcN]DTPA and [99mTcN]cysteine. Biological distribution studies in mice of these complexes showed that the presence of the nitrido group produced a radiopharmaceutical with different biological behaviour to that produced when conventional reduction methods are used with the same ligand. HPLC studies confirmed that the use of the 99mTcNCl-4 substitution route produced radiopharmaceuticals of high radiochemical purity.
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