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  • Title: cAMP-dependent protein kinases of rat pituitary GH3 cells.
    Author: Fabbro D, Bally K, Koudelka G, Jungmann RA, Eppenberger U.
    Journal: J Cyclic Nucleotide Protein Phosphor Res; 1985; 10(1):31-42. PubMed ID: 2984264.
    Abstract:
    Two isoenzymes (type I and type II) of cAMP-dependent protein kinases were found in GH3 cytosol, isozyme type II activity being the predominant form (approximately 90%). Photoaffinity labeling of GH3 cell extracts with 8-N3-[32P]cAMP revealed three cAMP-binding proteins exhibiting molecular weights of 53,000, 51,000 and 48,000, respectively. The latter represents the regulatory subunit of type I isoenzyme whereas the 53,000 and 51,000 cAMP-binding proteins correspond to two different molecular forms of the type II isoenzyme regulatory subunit which are phosphorylated by a cAMP-dependent mechanism.
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