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  • Title: The interaction between calcium and the activation of Na+, K+-ATPase by noradrenaline.
    Author: Haag M, Gevers W, Böhmer RG.
    Journal: Mol Cell Biochem; 1985 Mar; 66(2):111-6. PubMed ID: 2984541.
    Abstract:
    The interaction of noradrenaline, various cation chelators and calcium on Na+, K+-ATPase from rat cerebral cortex plasma membranes was studied. It was shown that chelation of inhibitory cations by EGTA, EDTA and dipyridyl activated Na+, K+-ATPase to the same extent as noradrenaline but at higher concentrations; increasing concentrations of EGTA depressed the activation by noradrenaline; calcium in the form of a calcium-EGTA buffer depressed Na+, K+-ATPase at physiological concentrations; the inhibition of Na+, K+-ATPase by calcium is dependent on the magnesium concentration in the assay and the inhibition by calcium was partially reversed by noradrenaline.
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