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  • Title: Effects of naloxone, beta-endorphin and ACTH on acquisition of schedule-induced polydipsia.
    Author: Tazi A, Dantzer R, Mormede P, Le Moal M.
    Journal: Psychopharmacology (Berl); 1985; 85(1):87-91. PubMed ID: 2984711.
    Abstract:
    A series of three experiments examined the possible involvement of endogenous opioid peptides in the development of schedule-induced polydipsia in rats. Repeated pretraining treatment with 2 mg/kg naloxone impaired acquisition of schedule-induced polydipsia, whereas the same treatment injected after training increased drinking. This later effect was time dependent, since a 30-min delay in the injection of naloxone resulted in a disappearance of its effect. Post-training injections of 10 micrograms/kg beta-endorphin or ACTH delayed the development of drinking. These findings are consistent with the hypothesis that endogenous opioid peptides modulate the development of schedule-induced polydipsia.
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