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  • Title: Is FDG-PET/CT Useful for Diagnosing Pulmonary Metastasis in Patients with Soft Tissue Sarcoma?
    Author: Hagi T, Nakamura T, Sugino Y, Matsubara T, Asanuma K, Sudo A.
    Journal: Anticancer Res; 2018 Jun; 38(6):3635-3639. PubMed ID: 29848720.
    Abstract:
    BACKGROUND/AIM: In patients with soft tissue sarcoma (STS), distinguishing small metastatic pulmonary nodules from benign ones remains difficult. This study aimed to determine the accuracy of 18F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) in detecting pulmonary metastasis and identify factors affecting sensitivity with STS. MATERIALS AND METHODS: The clinical records and chest CT and FDG-PET/CT scans of 102 patients with STS were reviewed to determine the presence of pulmonary nodules. RESULTS: A significant relationship was observed between nodule size and maximum standardized uptake value (SUVmax). For nodules smaller than 5 mm, only 10 out of 76 metastatic pulmonary nodules exhibited FDG accumulation, showing a weak correlation between nodule size and SUVmax Conclusion: The role of FDG-PET/CT in differentiating metastatic from benign pulmonary nodules was unsatisfactory, especially for small nodules. Careful follow-up using CT scan may still be appropriate for diagnosing pulmonary nodules smaller than 5 mm.
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