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  • Title: A mitochondria-targeting hetero-binuclear Ir(iii)-Pt(ii) complex induces necrosis in cisplatin-resistant tumor cells.
    Author: Ouyang C, Chen L, Rees TW, Chen Y, Liu J, Ji L, Long J, Chao H.
    Journal: Chem Commun (Camb); 2018 Jun 14; 54(49):6268-6271. PubMed ID: 29850704.
    Abstract:
    A hetero-binuclear Ir(iii)-Pt(ii) complex was developed as an antitumor agent. In vitro cytotoxicity results indicated that this complex was effective against cisplatin-resistant tumor cells. Mechanism experiments showed that it can overcome cisplatin resistance by increasing cellular uptake, targeting mitochondria, and inducing cell necrosis.
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