These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: The first reported case of factor V Leiden mutation with agenesis of superior vena cava: A case report.
    Author: De Souza VR, Lemos VMV, Lafayette DSA, Lemos RS, Fontes LBC, Lima GMT, Correia CWB, Domingues ALC, Aroucha AQDMS, Oliveira IM, Santos GP, Vanderlei AM, Lemos VMV, Peter JVS, Vieira JO, Mariano ARP, Gomes TA, Ferraz AMS, Amaral JHSD, Lins EM, Bezerra MAC, Araújo PSR, Vasconcelos AF, Correia MDCB, Costa MFH.
    Journal: Medicine (Baltimore); 2018 Jun; 97(22):e10511. PubMed ID: 29851773.
    Abstract:
    RATIONALE: Total absence of superior vena cava (ASVC) is a very rare anomaly, and the patient usually suffers from superior vena cava syndrome (SVCS) or conduction disturbances. PATIENT CONCERNS: We report a 36-year-old white male, born and living in Brazil, without comorbidities presented to hematologist thrombotic episodes even under anticoagulant therapy. On his first hematologic appointment, he had no active complaints except by the fullness after meals, and his physical examination presented remarkable collateral circulation in the chest. DIAGNOSES: Congenital ASVC associated with factor V Leiden mutation. OUTCOMES: In his magnetic resonance angiography of the thorax, a great amount of collateral circulation and communication of the azygos and hemiazygos veins with inferior vena cava were evident, as well as the absence of the upper cava vein. Furthermore, heterozygous genetic mutation was found for Leiden factor V. LESSONS: This case gives us the lesson that we need to include ASVC in the differential diagnosis of SVCS. The importance of the V-Leiden factor as a joint risk with this congenital defect for venous thromboembolism episodes was also highlighted.
    [Abstract] [Full Text] [Related] [New Search]