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  • Title: Phorbol ester-induced expression and function of the interleukin 2 receptor in human B lymphocytes.
    Author: Ando I, Crawford DH, Kissonerghis MA, Owen MJ, Beverley PC.
    Journal: Eur J Immunol; 1985 Apr; 15(4):341-4. PubMed ID: 2985401.
    Abstract:
    The expression of the interleukin 2 receptor (Tac) on normal B cells and Epstein-Barr virus-transformed lymphoblastoid B cell lines is induced by the tumor promoter 12-O-tetradecanoyl-phorbol-13-acetate (TPA). The receptor on B cells is indistinguishable from that on T cells by serological and biochemical analysis. It is functionally active so that TPA-induced B cells respond to interleukin 2 by increased DNA synthesis. These results suggest that the expression of Tac is not exclusively restricted to T cells and that interleukin 2 may play a role in B cell differentiation.
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