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  • Title: Further characterization of cardiodigin, Na+, K+-ATPase inhibitor extracted from mammalian tissues.
    Author: Fagoo M, Godfraind T.
    Journal: FEBS Lett; 1985 May 06; 184(1):150-4. PubMed ID: 2985443.
    Abstract:
    This study was undertaken to characterize endogenous digitalis-like activity in water extract from mammalian tissues. Prepurified samples obtained from guinea-pig heart were analysed by reverse-phase HPLC using an acetonitrile gradient. The eluent was assayed for its activity as inhibitor of human heart Na+, K+-ATPase and digoxin-like immunoreactivity. Both activities were recovered in the same fraction after two successive chromatographic steps. These results provide further evidence for the presence of an endogenous digitalis-like factor, cardiodigin, in mammalian heart.
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