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  • Title: Adduct formation is involved in radiosensitization, mediated by cytochrome c, of phi X174 DNA by misonidazole.
    Author: Lafleur MV, Plijmackers-Westmijze EJ, Loman AC, Loman H.
    Journal: Int J Radiat Biol Relat Stud Phys Chem Med; 1985 Apr; 47(4):379-82. PubMed ID: 2985519.
    Abstract:
    Radiosensitization by misonidazole of biologically active phi X174 DNA, mediated by cytochrome c, is most probably at least partly due to formation of an adduct between sensitizer and DNA, which can be removed from the DNA by a mild alkaline treatment thereby restoring the activity of the DNA.
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