These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: [Development of cardiac adenylate cyclase hypersensitivity to isoproterenol in the chronic action of propranolol on rats].
    Author: Tkachuk VA, Cherkasova TD.
    Journal: Probl Endokrinol (Mosk); 1985; 31(2):49-52. PubMed ID: 2986093.
    Abstract:
    The chronic treatment of rats with the beta-adrenergic antagonist propranolol causes a double increase in the amount of beta-adrenergic receptors in the cardiac membranes. The purpose of the paper is to investigate the effect of propranolol on the activity and regulatory properties of rat heart adenylate cyclase. Propranolol injections to rats for 3 weeks (10-20 mg/l kg bw) did not influence the enzyme basal activity but caused a rise of a degree of myocardial adenylate cyclase activation by isoproterenol and glucagon.
    [Abstract] [Full Text] [Related] [New Search]