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  • Title: Intracellular bicarbonate and pH of skeletal muscle in chronic renal failure.
    Author: Guariglia A, Antonucci C, Coffrini E, Del Canale S, Fiaccadori E, Reni F, Vitali P, Arduini U, Borghetti A.
    Journal: Proc Eur Dial Transplant Assoc Eur Ren Assoc; 1985; 21():881-7. PubMed ID: 2986103.
    Abstract:
    In 11 controls and 10 patients suffering from untreated uraemic acidosis intracellular bicarbonate and skeletal muscle pH (needle biopsy) were determined. In all patients a significant intracellular acidosis, not related to any extracellular indices was found. It is concluded that the chronic proton load is able to effect intracellular buffer composition; moreover the action of other factors such as derangements of cell metabolism and nutritional imbalance could be operating.
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