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  • Title: [Antipsychotic induced rhabdomyolysis].
    Author: Ratnam C, Saguin E, Keou S, Plantamura J, Mennessier C, Lahutte B, Delacour H.
    Journal: Ann Biol Clin (Paris); 2018 Jun 01; 76(3):329-335. PubMed ID: 29862972.
    Abstract:
    We report the case of a 40-year-old patient followed for post-traumatic stress disorder. A re-evaluation of its pharmacological treatment with the introduction of mirtazapine (30 mg/day) was associated with a rhabdomyolysis (CK> 20,000 IU/L at day 3). The diagnosis of mirtazapine induced rhabdomyolysis was made. After withdrawal of this drug combined with a symptomatic treatment (hydratation), the patient recovered well and was discharged without any nephrological sequelae. This article is intended to underline the diagnostic approach to elevated CK activity and the potential role of the "medical biologist" as a consultant for the relevant use of biological examinations. A physiopathological mechanism of this rhabdomyolysis is also proposed.
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