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  • Title: New insights on the cytochrome c oxidase proton pump.
    Author: Thelen M, O'Shea PS, Azzi A.
    Journal: Biochem J; 1985 Apr 01; 227(1):163-7. PubMed ID: 2986602.
    Abstract:
    Cytochrome c oxidase vesicles were used to show that, under appropriate experimental conditions: (1) no net deprotonation of the vesicular membrane or of the incorporated enzyme occurs during the oxidation of ferrocytochrome c; (2) the pH equilibration kinetics of a respiration-induced pH gradient across the bilayer are a simple function of the ohmic proton-conductance properties of the membrane; (3) a fairly constant stoichiometry (0.8-0.7) of the numbers of protons pumped per molecule of ferrocytochrome c oxidized, i.e. the H+/e- ratio, over a wide range of dioxygen molecules reduced (1-12) is observed.
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