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  • Title: Effect of propofol, thiopentone and etomidate on adrenal steroidogenesis in vitro.
    Author: Lambert A, Mitchell R, Robertson WR.
    Journal: Br J Anaesth; 1985 May; 57(5):505-8. PubMed ID: 2986662.
    Abstract:
    The i.v. anaesthetic agents propofol, thiopentone and etomidate inhibited ACTH-stimulated production of cortisol by guineapig dispersed adrenal cells in a dose-related manner. For two of the drugs, propofol and thiopentone, inhibition occurred over a similar concentration range: 2 X 10(-5) - 5 X 10(-4) mol litre-1. With etomidate, inhibition occurred over a much lower concentration range (5 X 10(-8) - 5 X 10(-6) mol litre-1). The concentrations of anaesthetic which induced 50% inhibition of cortisol secretion were propofol 1.7 X 10(-4), thiopentone 1.6 X 10(-4), and etomidate 1.0 X 10(-7) mol litre-1.
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