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  • Title: Glycosphingolipids of leukemic cells in adult T-cell leukemia-lymphoma.
    Author: Kuriyama M, Nomura K, Tara M, Matsubara H, Igata A.
    Journal: Biochim Biophys Acta; 1985 May 17; 834(3):396-401. PubMed ID: 2986706.
    Abstract:
    We analyzed lipids from leukemic cells of two patients with adult T-cell leukemia and compared them with those from T-cell lymphocytes of normal subjects. The neutral glycosphingolipids and gangliosides which were isolated were characterized by thin-layer chromatography and neuraminidase treatment. Both leukemic cells and normal lymphocytes had monoglycosylceramide and diglycosylceramide as major neutral glycosphingolipids. In one patient, diglycosylceramide was markedly increased. II3NeuAc-LacCer (GM3) and more complex gangliosides were detected in both cells. The most characteristic finding in leukemic cells was the occurrence of a disialylated ganglioside, II3(NeuAc)2-LacCer (GD3), which is not found in normal lymphocytes and neutrophils. This ganglioside may be due to the induced synthesis in association with malignant transformation.
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