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  • Title: Cytomegalovirus gp40/m152 Uses TMED10 as ER Anchor to Retain MHC Class I.
    Author: Ramnarayan VR, Hein Z, Janßen L, Lis N, Ghanwat S, Springer S.
    Journal: Cell Rep; 2018 Jun 05; 23(10):3068-3077. PubMed ID: 29874591.
    Abstract:
    The murine cytomegalovirus immunoevasin m152/gp40 binds major histocompatibility complex (MHC) class I molecules and retains them in the early secretory pathway by a previously unknown mechanism, preventing antigen presentation to CD8+ T cells. We show that retention of class I and of gp40 itself depends on a lumenal linker sequence in gp40. With unbiased co-immunoprecipitation and mass spectrometry, we find that, through this linker, gp40 binds to TMED10/Tmp21/p24δ1, a member of the p24 family of endoplasmic reticulum (ER)/Golgi transmembrane proteins. We show that the C-terminal KKxxx Golgi-to-ER retrieval signal of TMED10 is required for gp40-mediated retention of class I. We thus identify a viral interaction partner of the p24 proteins and their exploitation for viral immune evasion.
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