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  • Title: Fluoride Binding to Dental Biofilm Bacteria: Synergistic Effect with Calcium Questioned.
    Author: Nóbrega DF, Leitão TJ, Cury JA, Tenuta LMA.
    Journal: Caries Res; 2019; 53(1):10-15. PubMed ID: 29874637.
    Abstract:
    It has been suggested that fluoride binding to dental biofilm is enhanced when more bacterial calcium binding sites are available. However, this was only observed at high calcium and fluoride concentrations (i.e., when CaF2 precipitation may have occurred). We assessed fluoride binding to Streptococcus mutans pellets treated with calcium and fluoride at concentrations allowing CaF2 precipitation or not. Increasing calcium concentration resulted in a linear increase (p < 0.01) in fluoride concentration only in the pellets in which CaF2 precipitated. The results suggest that CaF2 precipitation, rather than bacterially bound fluoride, is responsible for the increase in fluoride binding to dental biofilm with the increase in calcium availability.
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