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  • Title: Effects of acute oral administration of lithium compounds on multiple schedule performance in rats.
    Author: Chrislip DW, Anger WK, Smith RJ.
    Journal: Neurobehav Toxicol Teratol; 1985; 7(1):39-42. PubMed ID: 2987718.
    Abstract:
    Adult male Sprague-Dawley rats were given acute oral administrations of lithium carbonate or lithium chloride at concentrations of 100, 200, and 300 mg/kg. Barpressing performance on a multiple fixed ratio 20/fixed interval 5 minute schedule was measured daily. The 200 and 300 mg/kg administrations of lithium chloride produced significant decreases in barpressing performance and all levels of lithium carbonate produced significant changes in performance. A 24 hour delay in the maximal behavioral effect of the 300 mg/kg dose of lithium carbonate paralleled previous findings showing delays in peak brain lithium levels after oral administration of lithium carbonate.
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