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  • Title: Antigenic heterogeneity among phylogenetic clusters of influenza D viruses.
    Author: Odagiri T, Ishida H, Li JY, Endo M, Kobayashi T, Kamiki H, Matsugo H, Takenaka-Uema A, Murakami S, Horimoto T.
    Journal: J Vet Med Sci; 2018 Aug 10; 80(8):1241-1244. PubMed ID: 29877211.
    Abstract:
    Influenza (flu) D virus, a possible causative agent of bovine respiratory disease, is genetically classified into three clusters: D/OK-, D/660-, and D/Japan-lineages. To evaluate antigenic heterogeneity among these clusters, we compared antibody titers to each lineage virus using bovine sera collected over time following virus infection. Antibody titers to D/Japan-lineage virus rose rapidly in the acute phase of infection, and were 4 times higher than those to the other clustered viruses. In the later phase of infection, titers to D/Japan-lineage virus were equivalent to those to D/OK-lineage virus, and still higher than those to D/660-lineage virus. These results suggest the existence of common and lineage-specific antigenic epitopes in the hemagglutinin-esterase-fusion protein of flu D viruses.
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