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  • Title: [Biochemistry and significance of prostaglandins, prostacyclins, thromboxanes and leukotrienes and the modification of their biosynthesis by essential fatty acids].
    Author: Kolb E.
    Journal: Z Gesamte Inn Med; 1985 Mar 15; 40(6):165-72. PubMed ID: 2988221.
    Abstract:
    A survey is given of the biochemistry and importance of the prostaglandins, the thromboxanes, the prostacyclins and the leukotrienes. The formation of these compounds takes place from poly-unsaturated fatty acids and is regulated: here the phospholipase A2 plays a role. Among others the prostaglandins take part in the regulation of the blood supply of various tissues (heart, kidneys), in the regulation of the reproduction and in the evokation of labour. The thromboxanes and prostacyclins influence the aggregation and the desaggregation of the thrombocytes, respectively. The leukotrienes take part in the regulation of the permeability of the capillaries, in the migration of the leucocytes, the formation of inflammatory processes and in the evokation of asthma bronchiale. The insufficient intake leads to functional disturbances in various tissues, which partly are to be traced back to a decrease of the formation of the tissue hormones mentioned. An intake transgressing the demand has a favourable effect in various diseases: thus the inclination to aggregation of the thrombocytes is decreased and the development of arteriosclerotic changes is inhibited.
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