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Title: Transformation of human fetal thymus and spleen lymphocytes by human T-cell leukemia virus type I. Author: Akagi T, Ohtsuki Y, Shiraishi Y, Miyoshi I. Journal: Acta Med Okayama; 1985 Apr; 39(2):155-9. PubMed ID: 2988287. Abstract: Co-cultivation of human thymus and spleen lymphocytes, which were obtained from 26-week and 27-week fetuses, with a lethally-irradiated human cord T-cell line harboring human T-cell leukemia virus type I (HTLV-I) resulted in the establishment of T-cell lines positive for adult T-cell leukemia-associated antigens and producing HTLV-I. These cell lines had the phenotype of a helper/inducer subset of peripheral T-cells as evidenced by the reactivity with monoclonal antibodies to human T-cells.[Abstract] [Full Text] [Related] [New Search]