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  • Title: Intrapulmonary shunt is not increased by 100% oxygen ventilation in acute respiratory failure.
    Author: Lemaire F, Matamis D, Lampron N, Teisseire B, Harf A.
    Journal: Bull Eur Physiopathol Respir; 1985; 21(3):251-6. PubMed ID: 2988676.
    Abstract:
    Increase of shunt has been demonstrated during short periods of pure oxygen breathing, mostly in patients with mild acute respiratory failure (ARF). Twenty patients with a large range of venous admixture (12 to 63%) were studied when FIO2 was increased from maintenance to one. Intrapulmonary shunt was measured with both the conventional oxygen method [QS/QT (O2)] and the multiple inert gas elimination technique [QS/QT (IG)]. Mean venous admixture decreased from 29 to 24% when FIO2 was increased and QS/QT (IG) remained unaltered. The pattern of blood flow distribution remained similar in both conditions, even in the eleven patients with ARF secondary to bacterial pneumonia and who had a low V/Q mode, highly liable to collapse with 100% oxygen. As no increase in shunt was documented in these patients, reluctance to measure shunt during 100% oxygen breathing should be re-evaluated.
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