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  • Title: Ketanserin does not prevent ACTH-induced hypertension in sheep.
    Author: Nelson MA, Coghlan JP, Denton DA, Whitworth JA, Scoggins BA.
    Journal: Clin Exp Pharmacol Physiol; 1985; 12(2):155-9. PubMed ID: 2988838.
    Abstract:
    The role of serotonin (5HT) in the pathogenesis of ACTH-induced hypertension in sheep has been examined. The pressor responses to injections of 5HT (0.1-30 micrograms/kg) were similar in normotensive and hypertensive sheep. Prior treatment with the 5HT2 receptor antagonist ketanserin had no effect on the development of hypertension produced by ACTH administration.
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