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  • Title: Southern analysis of DNA polymorphism among Dw subtypes of DR4.
    Author: Nicklas JA, Noreen HJ, Segall M, Bach FH.
    Journal: Hum Immunol; 1985 Jun; 13(2):95-103. PubMed ID: 2989225.
    Abstract:
    DNA from individuals of four Dw subtypes of DR4 (Dw4, Dw10, Dw14, Dw15) were studied using Southern blotting to determine if subtype-specific DR beta or DQ beta restriction fragment polymorphism could be found. Although very little polymorphism was found among ten DR4 homozygous individuals (4 Dw4, 2 Dw10, 3 Dw14, 1 Dw15) using a Dr beta or a DQ beta probe, restriction fragment polymorphism was easily detected between different DR types (DR1-DRw8). The possible evolutionary significance of the lack of Dw-associated polymorphism relative to DR-associated polymorphism is discussed.
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