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  • Title: Brain myelin of genetically obese mice.
    Author: Sena A, Sarliève LL, Rebel G.
    Journal: J Neurol Sci; 1985 May; 68(2-3):233-43. PubMed ID: 2989440.
    Abstract:
    Brain myelin was studied in genetically obese (ob/ob) mice and compared with that of normal (+/+) mice from the same strain. The brain from obese mice had a significantly lower amount of myelin, and marked changes in the fatty acid composition of myelin were observed. In contrast, the myelin cholesterol: phospholipid: galactolipid and the cerebroside: sulfatide molar ratios and also the phospholipid composition were normal. 2',3'-Cyclic nucleotide 3'-phosphohydrolase (CNP) and UDP-galactose ceramide galactosyltransferase (CGalT) enzymatic activities were normal, and 3'-phosphoadenosine 5'-phosphosulfate (PAPS): cerebroside sulfotransferase (CST) was only slightly decreased. Cholesterol esters were not present in the mutant. These results indicate that brain myelination is affected in obese mutant mice.
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