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  • Title: 2',3'-Cyclic nucleotide 3'-phosphohydrolase in acrylamide-induced optic neuropathy in rabbit.
    Author: Ohki K, Machi N, Matsushima S, Mizuno A.
    Journal: Jpn J Ophthalmol; 1985; 29(1):110-4. PubMed ID: 2989596.
    Abstract:
    The in vivo effects of acrylamide on the nerve tissues of the rabbit optic pathway were examined. The optic nerve of acrylamide-treated rabbits showed inflammatory changes and degeneration. The decrease of myelin was observed with myelin stain. The activity of 2',3'-cyclic nucleotide 3'-phosphohydrolase (EC.3.1.4.37) which is firmly bound to myelin was markedly diminished by acrylamide intoxication.
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