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  • Title: Use of heat-treated clotting-factor concentrates in patients with haemophilia and a high exposure to HTLV-III.
    Author: McGrath KM, Thomas KB, Herrington RW, Turner PJ, Taylor L, Ekert H, Schiff P, Gust ID.
    Journal: Med J Aust; 1985 Jul 08; 143(1):11-3. PubMed ID: 2989666.
    Abstract:
    In a group of 126 Australian patients with haemophilia, who were receiving lyophilized clotting-factor concentrates prepared from locally collected plasma, a high prevalence of antibody to human T-cell lymphotropic virus III (HTLV-III) was demonstrated in those with severe disease. Patients with moderate or mild disease had a much lower prevalence of HTLV-III antibody. After heat treatment of lyophilized factor VIII and factor IX concentrates (60 degrees C for 72 hours) to inactivate the virus, the losses of activity of an intermediate-purity and of a fibrinogen-poor factor VIII concentrate, and of the coagulant activity of a factor IX concentrate, were within acceptable limits. The solubility of the intermediate-purity factor VIII concentrate was markedly decreased; the fibrinogen-poor factor VIII concentrate and the factor IX concentrate were readily soluble. In-vivo recovery and survival of heated concentrates were equivalent to those of the unheated products, and they were effective in the treatment of spontaneous and traumatic haemorrhages.
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