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  • Title: Clinical Usefulness of Lipid Ratios to Identify Subclinical Atherosclerosis in Perimenopausal/Menopausal Women.
    Author: Tongdee P, Loyd RA, Kanoksin S, Kanjanawetang J, Winwan K, Nimkuntod P.
    Journal: J Med Assoc Thai; 2016 Oct; 99 Suppl 7():S36-41. PubMed ID: 29901900.
    Abstract:
    BACKGROUND: Evidence shows that lipid ratios perform better than individual lipids in predicting cardiovascular risk. The lipid ratio serves as a quick and simple tool for identifying subclinical atherosclerosis. The population at risk especially perimenopausal and menopausal women should be monitoring to prevent cardiovascular disease in the future. OBJECTIVE: To examine the association between lipid ratios and subclinical atherosclerosis by carotid intima media thickness (CIMT) in perimenopausal/menopausal women. MATERIAL AND METHOD: A cross-sectional study was conducted with 130 participants aged 40 to 80 years between February 2015 and January 2016 in Suranaree University of Technology Hospital, Thailand. CIMTs were assessed using a highresolution B mode ultrasound system. Traditional anthropometry, body mass index (BMI), waist circumference (WC), and parameters including blood pressure, fasting plasma glucose, lipid profile [Total cholesterol (TC), Triglyceride (TG), Highdensity lipoprotein cholesterol (HDL-C) and Low-density lipoprotein cholesterol (LDL-C)], and CIMT were assessed in all subjects. All lipid ratios were calculated. RESULTS: One hundred thirty perimenopausal/menopausal participants were included in this study. Of those participants, 41% were central obese phenotype and 22% had abnormal CIMT that can identify atherosclerosis. Age and systolic blood pressure in atherosclerosis group were higher than normal CIMT group; <0.01 and <0.01, respectively. Lipid ratio in normal CIMT was higher than atherosclerotic group but not statistically significance except TG/HDL-C (p = 0.03). All lipid ratios and single lipid parameters lacked prediction for the presence of early atherosclerosis. CONCLUSION: All of lipid ratios, TC/HDL-C, TG/HDL-C, and LDL-C/HDL-C were not identified as early subclinical atherosclerosis among perimenopausal/menopausal women.
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