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  • Title: In vitro efficacy of sulbactam combined with ampicillin against anaerobic bacteria.
    Author: Wexler HM, Harris B, Carter WT, Finegold SM.
    Journal: Antimicrob Agents Chemother; 1985 May; 27(5):876-8. PubMed ID: 2990330.
    Abstract:
    An ampicillin-sulbactam combination was compared with ampicillin alone, chloramphenicol, clindamycin, and metronidazole against 272 strains of anaerobic bacteria. Chloramphenicol and ampicillin-sulbactam were the most effective, inhibiting 98 to 99% of strains tested at breakpoint (16 micrograms/ml). The combination of sulbactam and ampicillin was much more effective than ampicillin alone against Bacteroides fragilis strains but did not differ substantially from ampicillin alone against Fusobacterium spp., gram-positive rods, and gram-positive cocci.
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