These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: [Effects of total favonoids of Ecommia umoides on atioxidant aility of imune ogans in lead poisoning mice].
    Author: Yuan D, Liu M, Nie H, Huang L.
    Journal: Wei Sheng Yan Jiu; 2016 Jul; 45(4):643-647. PubMed ID: 29903337.
    Abstract:
    OBJECTIVE: To explore the effects of total flavonoids of Eucommia ulmoides on antioxidant ability of immune organs in lead poisoning mice. METHODS: Fifty male mice were randomly divided into 5 groups, normal control group, lead group, positive control group, the total flavonoids of Eucommia ulmoides groups( 200, 50 mg / kg). The lead poisoning model was established by peritoneally injecting mice with 70 mg / kg lead acetate every day for 8 days. After the total flavonoids of Eucommia ulmoides was gavaged for 14 days, mice were sacrificed and immediately subjected to necropsy. The concentration of lead in blood, spleen and thymus were determined. The spleen and thymus index and the content of T-SOD、GSH-Px、T-AOC and MDA of spleen and thymus in mice were assayed. RESULTS: Intraperitoneal injection of 70 mg / kg lead acetate for 8 consecutive days could cause an immunity decline in lead poisoning mice, the total flavonoids of Eucommiaulmoides could significantly improve the immunity of lead poisoning mice. After the total flavonoids of Eucommia ulmoides was gavaged for 14 days, the viscera index in mice induced by lead acetate was significantly improve( P < 0. 01). Compared with lead group, the total flavonoids of Eucommia ulmoides( 200 mg / kg) could significantly reduce the lead contents in blood, spleen and thymus and improve the activities of T-SOD、GSH-Px、TAOC and reduce the content of MDA of mouse spleen and thymus( P < 0. 01), while there were no significant changes in concentrations of the lead contents in blood, spleen and thymus in the total flavonoids of Eucommia ulmoides( 50 mg / kg) treatment group. But the total flavonoids of Eucommia ulmoides( 50 mg / kg) could increase the activities of T-SOD、GSH-Px、T-AOC and reduce the content of MDA of mouse spleen and thymus in different degree. CONCLUSION: The total flavonoids of Eucommia ulmoides can effectively improve the antioxidant ability of immune organs in mice induced by lead acetate.
    [Abstract] [Full Text] [Related] [New Search]