These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Lateral Inhibition is a Neural Mechanism Underlying Mismatch Negativity.
    Author: Gu F, Wong L, Chen F, Huang WT, Wang L, Hu AX.
    Journal: Neuroscience; 2018 Aug 10; 385():38-46. PubMed ID: 29906551.
    Abstract:
    The human auditory change detection response known as mismatch negativity (MMN) is an auditory event-related potential that has been extensively used to investigate various aspects of human brain function and dysfunction. However, two competing views of the neural mechanism that underlie MMN have been a subject of debate for decades. The sensory memory hypothesis claims that the MMN reflects sensory memory-based change detection. The adaptation hypothesis argues that neural adaptation and lateral inhibition can fully explain the MMN. To date, there remains a lack of empirical evidence exploring whether lateral inhibition underlies MMN, which is a critical assumption of the adaptation hypothesis. In this study, an oddball paradigm was developed in which tone-pairs composed of two sinusoidal tones were presented as standards and deviants (e.g., a 330 Hz-392 Hz tone-pair was presented as standard, and a 392 Hz-330 Hz tone-pair was presented as deviant). The paradigm expected that two successive MMNs would be elicited by the two successive acoustic deviations in the deviant tone pairs, but when the two tones composing the tone-pairs were close in frequency, the first MMN would be attenuated in amplitude due to lateral inhibition. The results demonstrate that only one (the second) MMN was observed when the two tones were close in frequency (330 Hz and 392 Hz), but two MMNs were observed when the two tones were distant in frequency (330 Hz and 3135 Hz). These results suggest that lateral inhibition is a neural mechanism that underlies the MMN response.
    [Abstract] [Full Text] [Related] [New Search]