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  • Title: Cytotoxic and anti-inflammatory active phloroglucinol derivatives from Rhodomyrtus tomentosa.
    Author: Zhang YB, Li W, Jiang L, Yang L, Chen NH, Wu ZN, Li YL, Wang GC.
    Journal: Phytochemistry; 2018 Sep; 153():111-119. PubMed ID: 29906657.
    Abstract:
    Seven undescribed phloroglucinol derivatives, tomentodiones N-T, and eleven known ones were isolated from Rhodomyrtus tomentosa. Tomentodione N is the first example of a β-triketone unit coupled with an isoamyl alcohol through a furan fused-ring, and tomentodiones N, S, T were three racemates. The undescribed structures were elucidated by means of spectroscopic, X-ray diffraction, electronic circular dichroism calculation, and chemical methods. In addition, the isolated compounds were determined for the cytotoxic activities on HeLa cells and anti-inflammatory activities in LPS-stimulated RAW 264.7 cells.
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