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  • Title: Detection of antibodies to HTLV-I and -III in sera from Japanese hemophiliacs.
    Author: Abe T, Kinoshita T, Matsuda J, Ryu T, Ting RC, Aoki T, Robert-Guroff M, Miyakoshi H, Gallo RC.
    Journal: Cancer Res; 1985 Sep; 45(9 Suppl):4621s-4623s. PubMed ID: 2990696.
    Abstract:
    Sera from 50 Japanese hemophiliacs were screened for antibodies to human T-lymphotropic retrovirus types I and III (HTLV-I and -III). As a whole, antibody to HTLV-I, antibody to HTLV-III, and antibodies to HTLV-I and -III were detected in sera from 2, 17, and 6 hemophiliacs, respectively. Among them, two hemophiliacs developed acquired immunodeficiency syndrome who were positive for both antibodies to HTLV-I and -III in sera. All of the others were asymptomatic. Most of the blood products transfused into these hemophiliacs were imported from abroad, whence the source of HTLV-III infection presumably originated. However, since quite a high percentage of these antibody-positive hemophiliacs was positive for antibody to HTLV-I, even though they are native residents in HTLV-I nonendemic areas of Japan, some special factors may have participated in HTLV-I infection. These special factors should be investigated in the future.
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