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  • Title: Differential effects of dextrorphan and levorphanol on the excitation of rat spinal neurons by amino acids.
    Author: Church J, Lodge D, Berry SC.
    Journal: Eur J Pharmacol; 1985 May 08; 111(2):185-90. PubMed ID: 2990951.
    Abstract:
    The effects of the stereoisomers dextrorphan and levorphanol on the excitation of spinal neurons by electrophoretically administered excitatory amino acids were studied in pentobarbitone-anaesthetised rats. Both isomers reduced responses to N-methyl-DL-aspartate (NMA), dextrorphan being both more selective and more potent than levorphanol in this respect. This observation supports the proposal that the NMA-blocking activity of a variety of drugs with psychotomimetic properties is subserved by actions at phencyclidine (PCP)/sigma opiate receptors.
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