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  • Title: The amiloride sensitive Na+/H+ antiport in guinea pig pancreatic acini. Characterization and stimulation by caerulein.
    Author: Dufresne M, Bastie MJ, Vaysse N, Creach Y, Hollande E, Ribet A.
    Journal: FEBS Lett; 1985 Jul 22; 187(1):126-30. PubMed ID: 2991002.
    Abstract:
    Amiloride and analogs decrease the initial rate of 22Na+ uptake by dispersed acini from guinea pig pancreas in a dose-dependent manner. The initial rate of amiloride-sensitive 22Na+ uptake depends on external Na+ and H+ concentrations and on internal pH. These results provide evidence for the existence of a Na+/H+ antiport in pancreatic acinar cells. Caerulein, a cholecystokinin analog, stimulates the activity of the Na+/H+ antiport.
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