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  • Title: Thermodynamic limits to the stoichiometry of H+ pumping by mitochondrial cytochrome oxidase.
    Author: Murphy MP, Brown GC, Brand MD.
    Journal: FEBS Lett; 1985 Jul 22; 187(1):16-20. PubMed ID: 2991005.
    Abstract:
    H+/O stoichiometries of 0, 2 and 4 have been proposed for cytochrome oxidase. Here we show that a stoichiometry of 4 is thermodynamically impossible for rat liver cytochrome oxidase under normal conditions.
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