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  • Title: Three-dimensional structure of renal Na,K-ATPase determined by electron microscopy of membrane crystals.
    Author: Herbert H, Skriver E, Maunsbach AB.
    Journal: FEBS Lett; 1985 Jul 22; 187(1):182-6. PubMed ID: 2991007.
    Abstract:
    The three-dimensional structure of Na,K-ATPase was determined by electron microscopy and image processing. Tilt series of negatively stained membrane crystals were recorded. The projections were analyzed by Fourier methods and the data combined to a 3-D model. The unit cell contains two rod-shaped stain-deficient regions interpreted as alpha beta-promoters of Na,K-ATPase. The rods are related by dyad axes oriented perpendicular to the membrane. Outside the lipid bilayer the rods contact different protein units on the two sides of the membrane.
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