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  • Title: New 5'-nucleotidase inhibitors, melanocidin A and melanocidin B. I. Taxonomy, fermentation, isolation and biological properties.
    Author: Ogawara H, Uchino K, Akiyama T, Watanabe S.
    Journal: J Antibiot (Tokyo); 1985 May; 38(5):587-91. PubMed ID: 2991179.
    Abstract:
    New 5'-nucleotidase inhibitors named melanocidins A and B were produced by Nocardioides sp. 1681 J. They were isolated from fermentation broth by trichloracetic acid extraction, ethanol precipitation and CM-cellulose and DEAE-cellulose column chromatography. They inhibited 5'-nucleotidase activity from snake venom but not from rat liver membrane at 200 micrograms/ml. They also show antitumor activity against melanoma B16.
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