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  • Title: Sesquiterpene lactones from Centaurea rhizantha C.A. Meyer.
    Author: Shakeri A, Masullo M, Bottone A, Asili J, Emami SA, Piacente S, Iranshahi M.
    Journal: Nat Prod Res; 2019 Jul; 33(14):2016-2023. PubMed ID: 29911884.
    Abstract:
    Two new sesquiterpene lactones, rhizantholide A (1) and rhizantholide B (2), together with five known compounds (3-7) have been isolated from the aerial parts of Centaurea rhizantha (Asteraceae). Sesquiterpene lactones belong to guaianolide class, and rhizantholide B is a rare guaianolide characterized by a free primary alcoholic function at C-10 along with a 3β,10β-epoxy function. Their structures have been established on the basis of 1D and 2D NMR experiments, as well as HR-ESIMS. The antimicrobial activity of compounds 1-7 has been evaluated against Gram-positive and Gram-negative strains. Only deacylcynaropicrin 8-O-[3'-hydroxy-2'-methylpropionate] (5) showed moderate antibacterial activity against Staphylococcus aureus with a MIC/MBC value of 500 μg/mL. All isolated compounds have been also evaluated for their cytotoxic activities against cancer cells. Among them, compound 5 showed the highest cytotoxic activity with IC50 values in the range 5.02-16.76 μg/mL.
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