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  • Title: Age-related reductions in rat atrial high affinity choline uptake, ACh synthesis, and ACh release. A brief note.
    Author: Meyer EM, Esen Momol A, Baker SP.
    Journal: Mech Ageing Dev; 1985 May 13; 30(2):221-5. PubMed ID: 2991674.
    Abstract:
    We have developed a rat atrial mince preparation that can take up choline, acetylate it, and then release acetylcholine in a depolarization-dependent manner. We demonstrate that aging appears to reduce the functional cholinergic activity in this tissue, which may be important for understanding how senescence alters the regulation of cardiac activity.
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