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  • Title: Adrenergic receptors on cerebral microvessels in control and parkinsonian subjects.
    Author: Cash R, Lasbennes F, Sercombe R, Seylaz J, Agid Y.
    Journal: Life Sci; 1985 Aug 12; 37(6):531-6. PubMed ID: 2991685.
    Abstract:
    The binding of adrenergic ligands (3H-prazosin, 3H-clonidine, 3H-dihydroalprenolol) was studied on a preparation of cerebral microvessels in the prefrontal cortex and putamen of control and Parkinsonian subjects. The adrenergic receptor density in microvessels of control patients was less than 0.5% and 3.3% respectively of the total binding. A significant decrease in the number of alpha-1 binding sites was observed on microvessels in the putamen of patients with Parkinson's disease.
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