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  • Title: Removal of a 67-base-pair sequence in the noncoding region of protooncogene fos converts it to a transforming gene.
    Author: Meijlink F, Curran T, Miller AD, Verma IM.
    Journal: Proc Natl Acad Sci U S A; 1985 Aug; 82(15):4987-91. PubMed ID: 2991903.
    Abstract:
    Transformation of fibroblasts by protooncogene fos (c-fos) requires the linkage of viral long terminal repeat (LTR) sequences and interruption of 3'-noncoding sequences. We have identified an A + T-rich stretch of 67 nucleotides, located 627-693 base pairs downstream from the coding domain and 123-189 base pairs upstream from the putative poly(A) addition site, removal of which confers transforming activity to the c-fos gene. A novel regulation of the expression of the c-fos gene is proposed, which may be functional in vivo to prevent the gene from becoming an oncogene.
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