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  • Title: In Vitro Study of Antitumor Effect of Antimicrobial Peptide Tachyplesin I in Combination with Cisplatin.
    Author: Kuzmin DV, Emel'yanova AA, Kalashnikova MB, Panteleev PV, Ovchinnikova TV.
    Journal: Bull Exp Biol Med; 2018 Jun; 165(2):220-224. PubMed ID: 29922995.
    Abstract:
    We studied combined effect of β-hairpin antimicrobial peptide tachyplesin I and cytotoxic agent cisplatin on tumor and normal human cell lines. MTT assay and flow cytometry showed that tachyplesin I selectively sensitized cancer cells to cisplatin in specified concentration ratios. In vitro experiments demonstrated that combined use of tachyplesin I and cisplatin allows decreasing the effective dose of the cytostatic thus reducing nonspecific toxicity.
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